At least 120 people have been killed and 368 injured in an earthquake that hit a mountainous area of central Italy, PM Matteo Renzi has said.
The magnitude-6.2 quake struck at 03:36 (01:36 GMT), 100km (65 miles) north-east of Rome, not far from Perugia.
Eighty-six of the dead were in the historic town of Amatrice, where the mayor said three-quarters of the town was destroyed, and in nearby Accumoli.
Many people are still believed to be buried under rubble.
Rescue teams are using heavy lifting equipment and their bare hands as they continue to search for survivors after nightfall.
There were cheers in the village of Pescara del Tronto when an eight-year-old girl was pulled alive from the rubble after being trapped for 17 hours.
“This is not a final toll,” Mr Renzi warned as he gave the latest figures on a visit to the area.
He had earlier paid tribute to the volunteers and civil defence officials who had rushed to the scene in the middle of the night and used their bare hands to dig for survivors.